A tower block which contains 120 flats of 24 storeys high in the west London popularly known as the Grenfell tower has been brought down by fire.
The fire at Grenfell Tower on the Lancaster West Estate was reported at 01:16 BST and about 200 firefighters are tackling the blaze.
The Met Police said people were being treated for “a range of injuries”.
The BBC’s Andy Moore said the whole tower block was alight and there are fears the building might collapse.
Forty fire engines have been sent to the tower, and Mayor of London Sadiq Khan said a “major incident” had been declared.
At about 04:00 BST police said: “Residents continue to be evacuated from the tower block.”
The BBC’s Simon Lederman said the tower could be seen burning “from miles away”.
He said the building was “burning out of control”, from the tenth floor onwards.
London Fire Brigade assistant commissioner Dan Daly said firefighters are “working extremely hard in very difficult conditions to tackle this fire”.
“This is a large and very serious incident and we have deployed numerous resources and specialist appliances.”
The building is said to be managed by the Kensington and Chelsea Tenant Management Organisation (KCTMO) on behalf of the council.